Advances in automation and robotics are increasingly being integrated into sterile compounding equipment to improve accuracy and reduce contamination risks. Innovations such as automated compounding devices and improved environmental monitoring systems are becoming more prevalent, helping to ensure the sterility and quality of compounded medications. If you are trying to automate, let us know and we can help provide the best possible environment to run your equipment in.
Automated Compounding Devices (ACDs)
Automated compounding devices have revolutionized sterile compounding by improving accuracy, efficiency, and safety. These devices automate the process of preparing compounded sterile preparations (CSPs), minimizing human error and reducing the risk of contamination.
An example of an ACD on the market today is the ExactaMix system by Baxa, which automates the compounding of total parenteral nutrition (TPN) solutions. It precisely measures and mixes multiple ingredients, ensuring consistent and accurate preparation. At Aseptic Enclosures, we have successfully implemented the ExactaMix system into build designs for our clients, demonstrating our commitment to integrating advanced technologies into sterile compounding environments. See the image of the TPN Compounder CAI at the end of this section for an example of this.
Meanwhile, the Diana Compounding Workflow System enhances the compounding process by providing guidance, ensuring accuracy, and maintaining records, but it does not physically mix the medications. The physical mixing and preparation of compounded medications are still performed by the technician, following the system’s instructions and verification steps. However, it can be implemented with an automated system. It allows the user to scan patient barcodes along with the medication barcodes to ensure accuracy.
TPN Compounder CAI design with Baxter ExactaMix
Robotic Compounding Systems
Robotic systems take automation a step further by handling complex compounding tasks with minimal human intervention. These systems are designed to work in highly controlled environments to ensure sterility and precision.
Systems like the RIVA by ARxIUM fully automate the compounding of syringes and IV bags in an aseptic environment. It is capable of handling hazardous and non-hazardous drugs, significantly reducing the risk of contamination and exposure.
Environmental Monitoring Systems for Sterile Compounding Equipment
Advanced environmental monitoring systems are crucial in maintaining the sterile conditions required for compounding. These systems continuously monitor the compounding environment for particulates, microbial contaminants, and other factors that could compromise sterility.
Devices such as particle counters provide real-time monitoring of airborne particles in cleanrooms and other controlled environments. They help ensure compliance with regulatory standards by detecting and alerting to any deviations in air quality. At Aseptic Enclosures, we offer the AEPC 311, a reliable particle counter that includes software to monitor and analyze data efficiently.
Another innovative type of environmental monitoring system is a viable particle counter, which samples and detects airborne viable particles in cleanrooms and controlled environments. The viable particle sampler from Aseptic Enclosures captures microorganisms on a culture medium, allowing for subsequent incubation and identification. This process ensures the accurate monitoring of microbial contamination, which is essential for maintaining sterile conditions. The device is designed for ease of use and reliability, making it a valuable tool for any sterile compounding operation.
Closed System Transfer Devices (CSTDs)
CSTDs are designed to prevent the escape of hazardous drug vapors and aerosols during compounding and administration, protecting healthcare workers and patients.
The Equashield CSTD uses a double-membrane containment system to prevent drug exposure during preparation and administration. It is widely used in oncology and other fields where hazardous drugs are common. Additionally, they offer automated solutions that incorporate these safety measures.
Conclusion
Technological advancements in sterile compounding equipment, including automated compounding devices, robotic systems, and advanced environmental monitoring, are significantly enhancing the accuracy, efficiency, and safety of preparing compounded sterile preparations (CSPs). These innovations play a crucial role in reducing contamination risks and ensuring high-quality, sterile medications.
At Aseptic Enclosures, we specialize in providing a comprehensive range of aseptic solutions that can house and support these advanced compounding technologies. Our cleanrooms and isolators are designed to meet stringent regulatory standards, ensuring an optimal environment for the operation of equipment such as the ExactaMix systems, Diana Compounding Workflow System, and RIVA by ARxIUM. By partnering with Aseptic Enclosures, you can ensure that your compounding processes are conducted in a controlled, sterile environment, enhancing the safety and efficacy of your pharmacy operations.
For more information on our cleanroom solutions and how we can help you integrate these cutting-edge technologies into your compounding practices, don’t hesitate to get in touch with us today.
