Drugmaker tries again to win approval for “female Viagra”

WASHINGTON — The makers of a twice-rejected pill designed to boost female libido are resubmitting their drug to federal health regulators, following a recent lobbying blitz by politicians, women’s groups and consumer advocates aimed at pushing it onto the market.

Sprout Pharmaceuticals said Tuesday it is refiling its application for the drug, flibanserin, adding new information requested by the Food and Drug Administration about how the pill affects driving ability. FDA scientists requested that data after their most recent rejection of the drug, in part, due to results showing nearly 10 percent of women in company trials reported sleepiness as a side effect. The company studied women’s driving ability the morning after taking flibanserin compared with women taking placebo and a common sleeping pill..

If approved, Sprout’s daily pill would be the first drug for women who report a lack of sexual desire, a market that drugmakers have been trying to break into since the blockbuster success of Viagrafor men in the late 1990s. But the drug has already faced a long, winding review at the FDA because of lackluster effectiveness and side effects including fatigue, dizziness and nausea.

“The issues in the past were that the FDA didn’t feel the benefits really outweighed the risks, and they had some questions over safety in terms of how it interacts with other drugs somebody might be taking,” said CBS News medical contributor Dr. Tara Narula, a cardiologist at Lenox Hill Hospital in New York City.

In an effort to break the regulatory logjam, groups sponsored by Sprout and other drugmakers have begun publicizing the lack of a “female Viagra” as a women’s rights issue.

“Women deserve equal treatment when it comes to sex,” states an online petition to the FDA organized by one such group, Even the Score, which garnered almost 25,000 supporters. The group’s corporate backers include Sprout Pharmaceuticals, Palatin Technologies and Trimel Pharmaceuticals — all companies developing drugs to treat female sexual disorders. A spokeswoman for Blue Engine Media, the public relations group for Even the Score, declined to disclose how much of the group’s funding comes from companies. The group’s nonprofit supporters include the Women’s Health Foundation, the Institute for Sexual Medicine and other organizations.

The FDA first rejected flibanserin in 2010 after a panel of expert advisers unanimously voted against the drug, saying its benefits did not outweigh its risks. The drug’s initial developer, Boehringer Ingelheim, abandoned work on the drug in 2011 and sold it to Sprout, a startup headed by a husband-and-wife team from Raleigh, North Carolina.

Sprout resubmitted the drug with additional effectiveness and safety data, but the FDA again rejected the drug in October 2013. After Sprout filed a formal dispute over the decision, FDA regulators requested the driving study and other details on the drug’s interactions with other medications.

As Sprout gathered that data, the company also enlisted support from influential allies in Washington and beyond. Last January four members of Congress, including Rep. Debbie Wasserman Schultz, D-Florida, sent a letter to the FDA, urging a careful reassessment of the drug and lamenting the lack of drug options for low female libido.

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“There are 24 approved medical treatments for male sexual dysfunction and not one single treatment yet approved for the most common form of female sexual dysfunction,” states the letter, which was also signed by Rep. Louise Slaughter, D-New York, and two other Democratic congresswomen.

The talking point about the imbalance of drugs for men versus women was picked up by a coalition of seven women’s and consumer health groups who met with the FDA early last year.

“We see this not only as an important unmet women’s health issue, but an inflection point for the agency to ensure that similar standards are applied for drug approvals in conditions uniquely affecting women,” states a follow-up letter to the agency from leaders of the National Organization for Women, the National Consumers League and four other groups.

Then last October the FDA held a two-day meeting at its headquarters to get public input on the problem of female sexual dysfunction and the challenge of developing treatments.

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