Archives for March 2014


As pharmacists and technicians, we are an integral part of the delivery of health care to patients in a variety of practice settings. One of the most important changes that we can actively contribute to is the “Targeting Zero” initiative, created by the Association for Professionals in Infection Control and Epidemiology (APIC) to prevent the most common and fatal healthcare-associated infections (HAIs).

ANTT: a standard approach to aseptic technique.

Aseptic technique is the most commonly performed infection prevention procedure in healthcare; it is also probably the most critical. This article looks at the Aseptic Non Touch Technique (ANTT) model for reducing healthcare-associated infections (HCAI). It outlines the principles of ANTT and the approach to practice, and discusses the challenges health professionals still face in reducing HCAIs.

Verifying an Employee’s Aseptic Technique

Media-fill testing involving the manipulation of a suitable growth media (tryptic soy broth) represents one of the most objective methods of evaluating an employee’s knowledge and skill in asepsis. A media-fill or process-simulation test mimics an actual and entire compounding procedure, using a suitable growth medium, such as tryptic soy broth (TSB), in place of the typical ingredients to prepare a finished compounded preparation. According to USP Chapter <797>, media-fill testing also represents the most challenging or stressful conditions actually encountered by the personnel being evaluated when they prepare a compounded sterile preparation. In addition to verifying an individual’s ability, process-simulation testing can also be used to evaluate and identify the capabilities and weakness of aseptic compounding procedures that could contribute to the inaccuracy and/or contamination of the compounded sterile preparation. Using the Parenteral Drug Association’s Technical Report No. 22 (published in 1996) as a basis, a properly designed process-simulation test will be able to: