Archives for February 2014

Evaluation of compounding accuracy and aseptic techniques for intravenous admixtures.

Intravenous admixtures containing potassium collected from three hospital pharmacies were analyzed for compounding accuracy, sterility and pyrogenicity. The study was performed in two stages. During stage I, pharmacists and technicians were not informed of the study, but during stage II they were informed. In each stage 10 samples were collected from each person in the two personnel groups, analyzed and the results compared between the two personnel groups and the two stages. Results of the study showed that without monitoring (stage I) pharmacists had a higher mean percent error and contamination level than technicians. With monitoring, however, pharmacists showed a lower mean percent error and contamination level than technicians. Both personnel groups showed a decline in their mean percent error in the second stage, but there were still 83 (39.5%) errors in compounding accuracy greater than +/- 6%. No positive results with the Limulus test for pyrogens were obtained. It is recommended that a planned program of quality control be instituted for the preparation of i.v. admixtures by both pharmacists and technicians.

Demand for compounded drugs grows as awareness increases.

Michael Stringer mixed powders in a bowl Friday, grinding and stirring with mortar and pestle like a druggist from an earlier time.

Stringer, who owns Doctors Center Pharmacy on West Main Street, is one of a growing number of pharmacists practicing the old-school craft of compounding drugs.

A Practical to Aseptic Technique Verification: Policies and Procedures that Meet USP Chapter <797> Requirements.

ENSURING THAT PERSONNEL MAINTAIN GOOD ASEPTIC TECHNIQUE DURING all phases of the compounding process is critical to the sterility of the final CSPs (compounded sterile preparations). Good aseptic technique requires that personnel be properly trained through a didactic review of the principles of contamination control, and that they successfully demonstrate knowledge and skill through written and aseptic technique verification tests. Training will create a sense of importance, vigilance, and employee responsibility that helps to establish a culture of quality.